To undertake clinical functional genomics research in the critically ill and to develop related collaborative, laboratory based research projects with scientific colleagues.
To disseminate knowledge and promote understanding of functional genomics in the wider intensive care community.
To develop collaborations with colleagues outside the UK, with the particular objective of recruiting larger patient cohorts to achieve increased power and to allow replication.
We would like to encourage investigators in the field of Critical Care Medicine in the
UK to apply to the GAinS management committee for access to the archive, for
scientifically sound projects. Investigators should initially submit a short outline of their
proposed research to the committee and may be invited to subsequently submit a more
detailed plan of investigation.
Fairefax et al
. Genetics of gene expression
in primary immune cells identifies cell type-specific master regulators and
roles of HLA alleles. Nature Genetics 44, 502--510, 2012.
Maugeri N et al
Genetic determinants of
HSP70 gene expression following heat shock. Hum Mol Genetics
Fairfax BP et al
An integrated expression phenotype mapping approach
defines common variants in LEP, ALOX15 and CAPNS1 associated with
induction of IL-6. Hum Mol Genetics 2010;19(4):720--30
Eisen et al.
Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection. Clin Infect Dis. 2008 Aug 15;47(4):510-6.
Gordon AC, Knight J, Hinds CJ. (Editorial)
Genes and sepsis: How tight is the fit? Crit Care Med 2008; 36: 1652-1654.
Garrard CS, Hinds C, Knight JC
. Applications in critical care medicine. In: Kumar D, Weatherell D (eds) Genomics and Clinical Medicine 2007, Oxford University Press
Gordon et al.
Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome. Shock. 2006 Jan;25(1):88-93.
Gordon et al.
TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study. Genes Immun. 2004 Dec;5(8):631-40.